Novel process for the preparation of carboprost tromethamine

• 收藏
• 分享

专利权人:

Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt.

发明人:

Buzder-Lantos Peter,Dr. Kardos Zsuzsanna,Hortobagyi Iren,Laszlofi Istvan,Juhasz Imre,Fonagy Laszlo,Varadi Csaba,Nagyne Borko Agnes

申请号：

HU1500584

公开号：

HU1500584A2

申请日:

2015.12.01

申请国别(地区):

HU

年份:

2017

代理人:

摘要：

The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silicagel chromatography and the salt formation is carried out by using solid tromethamine base.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/