CHEN, ROGER SHEN-CHU,MULLER, GEORGE W.,JAWORSKY, MARKIAN S.,SAINDANE, MANOHAR T.,CAMERON, LOUISE
申请号：
ES11185767
公开号：
ES2402808T3
申请日:
2004.09.03
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
A process for preparing 3- (4-amino-1-oxo-1, a process for preparing 3- (4-amino-1-oxo-1,3-dihydro-isoindol-2-yl) -piperidine-2,6 -dione hemi3-dihydro-isoindol-2-yl) -piperidine-2,6-dione hemihydrate crystal, comprising the steps of: crystalline shidrato, comprising the steps of: suspending 3- (4-amino-1-oxo- 1,3-dihydro-isoindol-2-iuspender 3- (4-amino-1-oxo-1,3-dihydro-isoindol-2-yl) -piperidine-2,6-dione in water at l) - piperidine-2,6-dione in water at 70 ° C to 80 ° C for 6 to 24 hours filtering 3- (4-70 ° C to 80 ° C for 6 to 24 hours, filter 3- (4-amino-1-oxo-1,3-dihydro-isoindol-2-yl) -piperidine-amino-1-oxo-1 , 3-dihydro-isoindol-2-yl) -piperidine-2,6-dione and drying 3- (4-amino-1-oxo-1,3-dihydro-is2,6-dione and drying 3- (4-amino-1-oxo-1,3-dihydro-isoindol-2-yl) -piperidine-2,6-dione in vacuo. oindol-2-yl) -piperidine-2,6-dione in vacuo.Un procedimiento para preparar 3-(4-amino-1-oxo-1,Un procedimiento para preparar 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina-2,6-diona hemi3-dihidro-isoindol-2-il)-piperidina-2,6-diona hemihidrato cristalina, que comprende las etapas de: shidrato cristalina, que comprende las etapas de: suspender 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-iuspender 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina-2,6-diona en agua a una temperatura l)-piperidina-2,6-diona en agua a una temperatura de 70ºC a 80ºC durante 6 a 24 horas filtrar 3-(4-de 70ºC a 80ºC durante 6 a 24 horas filtrar 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina-2,6-diona y secar 3-(4-amino-1-oxo-1,3-dihidro-is2,6-diona y secar 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina-2,6-diona a vacio. oindol-2-il)-piperidina-2,6-diona a vacio.3-(4-氨基-1-氧代-1)的制备方法,3-(4-氨基-1-氧代-1,3-二氢-异吲哚-2-基)-哌啶-2,6-二酮半氢-二氢-异吲哚-2-基)-哌啶-2,6-二酮半水合物晶体的制备方法,包括以下步骤:结晶Shidrato,包括悬浮3-(4-a)的步骤1-氧代-1,3-二氢-异吲哚-2- I- 3 -(4-氨基-1-氧代-1)3-二氢-异吲哚-2-基)-哌啶-2,6-二酮-1-哌啶-2,6-二酮-2,6-二酮-水,70℃至80℃过滤6-24小时,3-(4-氨基-1-氧代-1,3-二氢-异吲哚-2-
