GORE VINAYAK GOVIND,SHUKLA VINAY KUMAR,BHANDARI SHERYAS,HASBE SURESH
申请号：
IN7366/DELNP/2011
公开号：
IN2011DN07366A
申请日:
2011.09.26
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The present invention relates to improved processes for preparing 3-(4-amino-l-oxo-l,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (I)(lenalidomide) and its intermediate 3-(l-oxo-4-nitro-l,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione. The present invention further relates to improved processes for preparing lenalidomide crystalline form A, use of said crystalline form A as an active pharmaceutical ingredient or as an intermediate in the preparation of further crystalline or amorphous forms of lenalidomide, compositions comprising lenalidomide crystalline form A and their use in the treatment of disease.
