Improved process

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专利权人:

Generics [UK] Limited

发明人:

Gore, Vinayak Govind,Shukla, Vinay Kumar,Bhandari, Shreyas,Hasbe, Suresh

申请号：

AU2010220204

公开号：

AU2010220204B2

申请日:

2010.03.01

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The present invention relates to improved processes for preparing 3-(4-amino-1-oxo-1,3- dihydro-isoindol-2-yl)-piperidine-2,6-dione (I) (lenalidomide) and its intermediate 3-(1-oxo- 4-nitro-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione. The present invention further relates to improved processes for preparing lenalidomide crystalline form A, use of said crystalline form A as an active pharmaceutical ingredient or as an intermediate in the preparation of further crystalline or amorphous forms of lenalidomide, compositions comprising lenalidomide crystalline form A and their use in the treatment of disease.

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