SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE;UNIVERSITAT BASEL;UNIVERSITAT ZURICH;VIROMETIX AG
发明人:
GHASPARIAN, ARIN,ZUNIGA, ARMANDO,GEIB, NINA,TAMBORINI, MARCO,JUD, MAJA,PLUSCHKE, GERD,MARRERO NODARSE, ANIEBRYS,ROBINSON, JOHN ANTHONY
申请号：
CA2931570
公开号：
CA2931570A1
申请日:
2014.12.02
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
