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PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE
专利权人:
VIROMETIX AG;SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE;UNIVERSITÄT BASEL;UNIVERSITÄT ZÜRICH
发明人:
Arin Ghasparian,Armando Zuniga,Nina Geib,Marco Tamborrini,Maja Jud,Gerd Pluschke,Aniebrys Marrero Nodarse,John Anthony Robinson
申请号:
US15908306
公开号:
US20180256698A1
申请日:
2018.02.28
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
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