CHEN, WEN CHENG,陈文正,陳文正,HUNG, CHUN CHENG,洪纯正,洪純正,KO, CHIA LING,柯嘉泠,柯嘉泠
申请号：
TW098119682
公开号：
TWI427050B
申请日:
2009.06.12
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The invention provides a calcium phosphate bone cement, a precursor and a fabrication method thereof. The fabrication method comprises: (a) dissolving a calcium phosphate with a low Ca/P atomic ratio in an acid solution, wherein the Ca/P atomic ratio is less than 1.33 (b) adding a calcium phosphate compound into the acid solution to obtain a reaction solution (c) allowing the reaction solution to stand to grow nanocrystallizes on surfaces of the calcium phosphate with low Ca/P atomic ratio (d) filtering and drying the solution of step (c) to obtain a calcium phosphate powder with low Ca/P atomic ratio having nanocrystallize on the surface and (e) mixing the powder of step (d) and a calcium phosphate powder with a high Ca/P atomic ratio.本發明提供一種鈣磷酸鹽類骨水泥(calcium phosphate bone cement,CPC)、其前驅物及其製法。製法包括以下步驟:(a)將一低鈣磷酸鹽溶於一酸性溶液中,其中低鈣磷酸鹽之Ca/P原子數比小於1.33;(b)加入一磷酸鈣化合物於酸性溶液中以形成一反應物溶液;(c)將反應物溶液靜置進行長晶反應,使低鈣磷酸鹽之表面披覆一奈米晶體(nanocrystalline);(d)將步驟(c)之溶液過濾烘乾,得到一表面披覆奈米晶體之低鈣磷酸鹽粉末;以及(e)將表面披覆奈米晶體之低鈣磷酸鹽粉末與一高鈣磷酸鹽粉末混合。
