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用於給藥、保存、搬運或輸送具有蛋白質低吸附性的蛋白質或包含蛋白質的組合物的容器,以及用於製造蛋白質或蛋白質組合物的器具
专利权人:
OTSUKA PHARMACEUTICAL FACTORY, INC.;DAIKIN INDUSTRIES, LTD.
发明人:
KOMAZAWA, KOZUE,驹泽梢,駒澤梢,HIGUCHI, TATSUYA,樋口达也,樋口達也,KIGAWA, KOJI,木河浩司,OBATA, KAZUAKI,小幡和哲,DEMPO, TAKAYUKI,传宝孝之,傳寶孝之,NISHIMURA, MASUHIRO,西村益浩
申请号:
TW106145329
公开号:
TW201827034A
申请日:
2017.12.22
申请国别(地区):
TW
年份:
2018
代理人:
摘要:
A container and an apparatus for producing a protein or a protein-containing composition, in each of which the surface to be contacted with the protein or the protein-containing composition is made from a fluororesin, wherein the fluororesin is at least one fluororesin selected from a tetrafluoroethylene-hexafluoropropylene copolymer and a tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer and has a melting point of 320 DEG C or lower and the total number of non-fluorinated group terminals and -CF2H group terminals is 70 or less per 1*106 carbon atoms. The container and the apparatus have significantly low protein adsorbability. When the container or the apparatus is used, it becomes possible, for example, to prevent the loss of a protein preparation such as an antibody drug due to the adsorption of the protein preparation onto an apparatus in the process of production (e.g., culture, purification) of the protein preparation, the process of storage or delivery of the protein preparation, or the administration of the protein preparation.藉由選自四氟乙烯-六氟丙烯類共聚物及四氟乙烯-全氟烷基乙烯基醚類共聚物的至少一種氟樹脂,且在熔點為320℃以下的氟樹脂中的非氟化基末端和-CF2H基末端的總數為每1×106個碳時在70個以下的氟樹脂,形成有與蛋白質或包含蛋白質的組合物接觸的表面的容器及用於製造蛋白質或包含蛋白質的組成物的器具,具有顯著的蛋白質低吸附性。當使用這種容器或器具,例如在抗體醫藥品等蛋白質製劑的製造(培養、精製等)工序、保存搬運工序或給藥時,可防止該蛋白質製劑吸附至器具導致的損失。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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