Containers for administration, storage, transportation, or transportation of proteins or protein-containing compositions having low protein adsorptivity and equipment for producing proteins or protein compositions
Non-fluorination in a fluororesin which is at least one fluororesin selected from a tetrafluoroethylene-hexafluoropropylene copolymer and a tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer and has a melting point of 320 ° C. or less. A container in which a surface in contact with a protein or a composition containing protein is formed by a fluororesin having a total number of base ends and -CF2H base ends of 70 or less per 1 × 10 6 carbon, and the protein or protein is included The equipment for producing the composition has a pronounced low protein adsorption. When such a container or equipment is used, loss due to adsorption of the protein preparation to the equipment can be prevented, for example, in the production (culture, purification, etc.) process, storage / transport process and administration of protein preparations such as antibody drugs. .テトラフルオロエチレン－ヘキサフルオロプロピレン系共重合体、及びテトラフルオロエチレン－パーフルオロアルキルビニルエーテル系共重合体から選ばれる少なくとも１つのフッ素樹脂であり、かつ融点が３２０℃以下であるフッ素樹脂における非フッ素化基末端と－ＣＦ２Ｈ基末端とを合計した数が炭素１×１０６当たり７０個以下であるフッ素樹脂により、タンパク質若しくはタンパク質を含む組成物と接触する表面が形成されている容器及びタンパク質若しくはタンパク質を含む組成物の製造用器材は顕著なタンパク質低吸着性を有する。かかる容器または器材を用いると、例えば、抗体医薬品等のタンパク質製剤の製造（培養・精製等）工程、保存・搬送工程や投与時において、該タンパク質製剤の器材への吸着によるロスを防ぐことができる。
