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Cicloalquenopirazoles sustituidos como inhibidores de BUB1 para el tratamiento del cáncer
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
HITCHCOCK, Marion,HILGER, Christoph-Stephan,MENGEL, Anne,BRIEM, Hans,HOLTON, Simon,PÜTTER, Vera,SIEMEISTER, Gerhard,PRECHTL, Stefan,FERNANDEZ-MONTALVAN, Amaury,STEGMANN, Christian,PREUSSE, Cornelia,GN
申请号:
ES13721755
公开号:
ES2620316T3
申请日:
2013.05.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I). ** ** Formula wherein R1 / R2 are independently hydrogen, halogen, hydroxy, C1-3alkyl, C1-3alkoxy, haloC1-3alkyl, haloC1-3alkoxy R3 is, independently, hydrogen, C1-6 alkoxy, halogen, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C3-6 cycloalkyl, C1-6 haloalkoxy, cyano, C (O) NR16R17, n is 1, 2, 3, R4 is (a) hydrogen, (b) hydroxy, (c) C1-6 alkoxy which is optionally substituted by (c1) 1-2 OH, (c2) NR11R12, (c3) -S - (C1-6 alkyl), (c4) -S (O) - (C1-6 alkyl), (c5) -S (O) 2- (C1-6 alkyl), ** ** Formula in which * is the point of attachment, (e) NR13R14, (f) NHC (O) -C1-6alkyl optionally substituted with hydroxy, C1-3alkoxy, (g) NHC (O) NH-C1-6 alkyl optionally substituted with hydroxy, C1-3alkoxy, (h) ** ** Formula in which * is the point of attachment, R5 is (a) hydrogen, (b) C1-6 alkyl, (c) - (C1-6 alkylene ) -O- (C1-3 alkyl), (d) C2-6 hydroxyalkyl, (e) -C (O) - (C1-6 alkyl), (f) -C (O) - (C1-6 alkylene) -OR - (C1-6 alkyl), (g) - (C2-6 alkylene) -NR11R12, R6 is (a) hydrogen, (b) halogen, (c) cyano, (d) C (O) NR16R17, (e) C (O) OR 15, m is 1.2, R9 is (a) hydrogen, (b) NR13R14, (c) -NH-C (O) - (C1-6 alkyl), (d) -NH-C ( O) - (C1-6 alkylene) -O- (C1-6 alkyl), (e) ** ** Formula in which * is the point of attachment, (f) hydroxy, (g) C1-6 alkoxy , p is 1, 2, R11, R12 are, independently, hydrogen, C1-6 alkyl or R11 and R12 together with the nitrogen atom to which they are attached form a cyclic amino group of 4 to 7 members, in which, for the cyclic amino group of 6 to 7 members, a methylene group can be replaced by a heteroatom selected from N, O or S, R13, R14 are, independently, hydrogen, C1-6 alkyl, or R13 and R14, together with the nitrogen atom to which they are attached form a cyclic amino group of 4 to 7 members, wherein, for the cyclic amino group of 6 to 7 members, a methylene group can be replaced by a heteroatom selection ed from N, O or S, R15 is hydrogen, C1-6 alkyl, R16, R11 are, independently, hydrogen, C1-6 alkyl or R16 and R17 togeth
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