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2H-chromene derivatives as sphingosine 1-phosphate receptor stimulants
专利权人:
Astellas Pharma Inc.
发明人:
HARADA, Hironori,HATTORI, Kazuyuki,FUJITA, Kazuya,IMADA, Sunao,MOROKATA, Tatsuaki
申请号:
ES09830473
公开号:
ES2570155T3
申请日:
2009.12.04
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A 2H-chromene compound represented by the following formula (I) or a salt thereof: ** Formula ** in which: A represents C1-6 alkyl, cycloalkyl, aryl or heteroaryl, in which the aryl and heteroaryl groups they can each be substituted with 1-R1 which are the same or different; R 1 represents halogen, -CN, -NO 2, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 halogenoalkyl, aryl, heteroaryl, cycloalkyl, -OH, -O- (C 1-6 alkyl), - O- (C1-6 halogenoalkyl), -O- (aryl), -O- (cycloalkyl), -O- (heteroaryl), -NH2, - NH (C1-6 alkyl), -NH (C1-6 halogenoalkyl) , -N (C1-6 alkyl) 2 or cyclic amino, in which the aryl, heteroaryl, cycloalkyl and cyclic amino groups can each be substituted with 1-5 substituents that are the same or different and are selected from halogen, -CN , C1-6 alkyl and C1-6 halogenoalkyl; L represents C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, - (C1-6 alkylene) -O-, -O- (C1-6 alkylene) - or - (C1-6 alkylene) - O- ( C1-6 rent) -; Q represents -C (R2B)>; = C (R2c) -; R2A, R2B and R2C are the same or different and represent -H, halogen, C1-6 alkyl, halogen C1-6 alkyl, -O- (C1-6 alkyl) or -O- (halogen C1-6 alkyl); Y represents O; m represents 0; R 3 represents -H, halogen, C 1-6 alkyl, C 1-6 halogenoalkyl or aryl; R4A represents -H or C1-6 alkyl; R4B represents C1-6 alkyl substituted with a group G, or cycloalkyl substituted with a group G; or R4A and R4B are combined with the N to which they are attached forming a cyclic amino group substituted with a group G, the cyclic amino group optionally having additionally 1-4 substituents that are the same or different and are selected from halogen, C1-6 alkyl and C1-6 halogenoalkyl; and the group G is -C (>; = O) OH, tetrazolyl, -C (>; = O) NHS (>; = O) 2 (C1-6 alkyl), - (C1-6 alkylene) -C (>; = O ) OH or ** Formula **Un compuesto de 2H-cromeno representado por la siguiente fórmula (I) o una sal del mismo:**Fórmula** en la que: A representa alquilo C1-6, cicloalquilo, arilo o heteroarilo, en los que los
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