PROBLEM TO BE SOLVED: To provide a novel method for activating soluble guanylate cyclase (sGC) independently of nitric oxide (NO). SOLUTION: A compound represented by the following formula I. ((JC) p-ring C is a substitutable monocyclic 5-membered heteroaryl group such as a substitutable isoxazolyl group； (JB) n-ring B is a substitutable phenyl group, phenyl, one or two ring-constituting nitrogens. Ato-containing Substitutable 6-membered Heteroaryl Group or Thienyl Group； X1 is CH, N, etc .； JA is H, Halogen, etc .； JD is H, Halogen, etc .； N (R1) R2 is Substitutable Amino Group, Substitutable Nitrogen-containing heterocyclic group, etc.) [Selection diagram] None【課題】可溶性グアニル酸シクラーゼ（ｓＧＣ）を一酸化窒素（ＮＯ）非依存的に活性化する新規方法の提供。【解決手段】下式Ｉで表わされる化合物。（（ＪＣ）ｐ－環Ｃは置換可イソキサゾリル基等の置換可単環式５員ヘテロアリール基；（ＪＢ）ｎ－環Ｂは置換可フェニル基、フェニル、、１若しくは２個の環構成窒素原子を含有する置換可６員ヘテロアリール基、又はチエニル基；Ｘ１はＣＨ、Ｎ等；ＪＡはＨ、ハロゲン等；ＪＤはＨ、ハロゲン等；Ｎ（Ｒ１）Ｒ２は置換可アミノ基、置換可含窒素複素環基等。）【選択図】なし
