Institut National de la Sante et de la Recherche Medicale (INSERM);Institut Pasteur de Lille;Universite Droit et Sante Lille II
发明人:
Camille Locht,Nathalie Mielcarek,Hana Kammoun
申请号：
US14682155
公开号：
US09528086B2
申请日:
2015.04.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A genetically attenuated Bordetella pertussis strain includes a mutated pertussis toxin (ptx) gene, and a heterologous ampG gene, and a hybrid protein including the N-terminal fragment of filamentous haemagglutinin (FHA) and a heterologous epitope or antigenic protein or protein fragment, different from FHA. The strain can be used in an attenuated vaccine for the treatment or prophylaxis of an infectious disease.
