Recombinant adenylate cyclase toxin of bordetella induces T cell responses against tumoral antigens

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专利权人:

发明人:

申请号：

EP09177668.2

公开号：

EP2193804B1

申请日:

2004.11.19

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA-A*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyA-E5-Tyr and CyaA-E5-GnT-V.

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