Gilles DADAGLIO,Claude Leclerc,Daniel Ladant,Benoit Van Den Eynde,Sandra Morel,Cecil Bauche
申请号：
US14063164
公开号：
US20140227323A1
申请日:
2013.10.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
