The invention relates to a recombinant Pasteurella multocida toxin, having at least one epitope of Pasteurella multocida toxin. When there is a plurality of the epitopes, the epitopes can be linked together with linkers. The recombinant Pasteurella multocida toxin further has at least one unit of the amino acid sequence of complement C3d, and the epitopes and the amino acid sequence of complement C3d can be linked with linkers. The invention also relates to nucleotide sequences encoding the recombinant Pasteurella multocida toxin and immunogenic compositions containing the recombinant Pasteurella multocida toxin against atrophic rhinitis.本發明係關於一種敗血性巴氏桿菌(Pasteurella multocida)毒素重組蛋白，包含至少一個敗血性巴氏桿菌毒素蛋白的抗原決定位；當該抗原決定位為複數個時，各抗原決定位之間可由連接子連接。該重組蛋白進一步可包含至少一個單元的補體裂解片段C3d的胺基酸序列，且該抗原決定位與該補體裂解片段C3d的胺基酸序列可以連接子連接。本發明並關於一種編碼如上述敗血性巴氏桿菌毒素重組蛋白的核苷酸序列，以及一種含有上述敗血性巴氏桿菌毒素重組蛋白的豬萎縮性鼻炎免疫組合物。
