The present Invention relates to dihidropirimidinonas biciclicas replaced Formula 1 and their use as inhibitors of Elastase activity, Pharmaceutical compositions containing it and its methods of use as agents for the treatment and \/ or prevention of diseases. Ulmonares, Gastrointestinal and Genitourinary Tracts.Inflammatory diseases of the skin and the eye, and other autoimmune and allergic disorders, oncological diseases and Allograft Rejection.Preferred compounds are: 4 - (2 - [1 - (3 - (trifluoromethyl) phenyl) - - - - hexahidro 2,3,4,5,6,7 1h cyclopenta [d] pyrimidin-4-yl) benzonitrile 4 - (3 - methyl - 2 - [1 - (3 - (trifluoromethyl) phenyl) - - hexahidro 2,3,4,5,6,7 - 1H cyclopenta [d] pyrimidin-4-yl) benzonitrile, among othersLa presente invencion se refiere a dihidropirimidinonas biciclicas sustituidas de la formula 1 y a su uso como inhibidores de la actividad de elastasa neutrofilica, a composiciones farmaceuticas que la contienen y sus metodos de uso como agentes para el tratamiento y/o prevencion de enfermedades pulmonares, gastrointestinales y genitourinarias, enfermedades inflamatorias de la piel y el ojo y otros trastornos autoinmunes y alergicos, rechazo a aloinjerto y enfermedades oncologicas. Los compuestos preferidos son: 4-(2,5-Dioxo-1-(3-(trifluorometil)fenil)-2,3,4,5,6,7-hexahidro-1H-ciclopenta[d]-pirimidin-4-il)benzonitrilo 4-(3-Metil-2,5-dioxo-1-(3-(trifluorometil)fenil)-2,3,4,5,6,7-hexahidro-1H-ciclopenta[d]pirimidin-4-il) benzonitrilo, entre otros
