CHRISTIAN GNAMM,THORSTEN OOST,STEFAN PETERS,HOLGER HOESCH,UWE JÖRG RIES
申请号：
PT14705723
公开号：
PT2953943T
申请日:
2014.02.05
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
