Lynn Macdonald,Cagan Gurer,Karolina A. Hosiawa,Sean Stevens,Andrew J. Murphy
申请号：
US13716238
公开号：
US20130160153A1
申请日:
2012.12.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.
