Lynn Macdonald,Cagan Gurer,Karolina A. Meagher,Sean Stevens,Andrew J. Murphy
申请号：
US13951996
公开号：
US09622459B2
申请日:
2013.07.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.
