МАКДОНАЛЬД, Линн (US),ГУРЕР, Цаган (US),ХОСИАВА, Каролина, А. (US),СТИВЕНС, Шон (US),МЕРФИ, Эндрю, Дж. (US)
申请号：
RU2018119366
公开号：
RU2018119366A
申请日:
2012.12.17
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.
