CYRIL JOHN COOK,DASTAGIRI DUDEKULA,FARMAN ULLAH,MARC LABELLE,NEERJA SARASWAT,RAMKRISHNA REDDY VAKITI,RUI ZHANG,THOMAS BOESEN,YING YANG
申请号：
BR112017003442
公开号：
BR112017003442A2
申请日:
2015.08.26
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present application relates to the compounds of formula (i), (ii), (iii), (iv), (v), (vi), (iiia), (iiib), (iiic), (hid) , (hie), (iiif), and (iiig). The compounds of formula (I) have the structure: (i) wherein q, r1, r18, r19, m, a and y are as defined herein. The subject compounds may modulate the activity of histone demethylases (hdmes), and may be useful for the prevention and / or treatment of diseases in which genomic dysregulation is involved in pathogenesis, for example cancer.o presente pedido refere-se aos compostos sendo de fórmula (i), (ii), (iii), (iv), (v), (vi), (iiia), (iiib), (iiic), (hid), (hie), (iiif), e (iiig). os compostos de fórmula (i) têm a estrutura: (i) em que q, r1, r18, r19, m, a e y são como aqui definidos. os compostos do pedido podem modular a atividade de histona desmetilases (hdmes), e podem ser úteis para a prevenção e/ou tratamento de doenças em que a desregulação genômica está envolvida na patogênese, por exemplo, câncer.
