Thomas Boesen,Marc Labelle,Ying Yang,Neerja Saraswat,Dastagiri Dudekula,Cyril John Cook,Ramkrishna Reddy Vakiti,Rui Zhang,Farman Ullah
申请号：
US14836397
公开号：
US20160102096A1
申请日:
2015.08.26
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present application relates to compounds being of Formula (I), (II), (III), (IV), (V), (VI), (IIIa), (IIIb), (IIIc), (IIId), (IIIe), (IIIf), and (IIIg). Compounds of Formula (I) have the structure:wherein Q, R1, R18, R19, M, A and Y are as defined herein. The compounds of the application can modulate the activity of histone demethylases (HDMEs), and can be useful for the prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, e.g., cancer.
