COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES

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专利权人:

INC.;GILEAD SCIENCES

发明人:

BOESEN, THOMAS,LABELLE, MARC,YANG, YING,SARASWAT, NEERJA,DUDEKULA, DASTAGIRI,COOK, CYRIL JOHN,VAKITI, RAMKRISHNA REDDY,ZHANG, RUI,ULLAH, FARMAN

申请号：

SG11201701182V

公开号：

SG11201701182VA

申请日:

2015.08.26

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

The present application relates to compounds being of Formula (I), (II), (III), (IV), (V), (VI), (IIIa), (IIIb), (IIIc), (IIId), (IIIe), (IIIf), and (IIIg). Compounds of Formula (I) have the structure: wherein Q, R1, R18, R19, M, A and Y are as defined herein. The compounds of the application can modulate the activity of histone demethylases (HDMEs), and can be useful for the prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, e.g., cancer.

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