Use of aminophenylbenzotriazole derivatives for protecting human and animal skin and hair from the harmful effects of UV radiation and cosmetic compositions thereof
Disclosed is a 2- (2'-hydroxy-4'-aminophenyl) benzotriazole derivative of formula (1) for protecting human and animal hair and skin from harmful effects of UV radiation: In the formula, R 1 and R 4 are independently of each other hydrogen； C 1 -C 28 alkyl； C 1 -C 28 alkoxy； C 2 -C 28 alkenyl； C 2 -C 28 alkynyl； C 3 -C 12 cycloalkyl； C 3 -C 12 cycloalkenyl； C 7 -C 28 Aralkyl； C 1 -C 20 heteroalkyl； C 3 -C 12 cycloheteroalkyl； Or C 5 -C 16 Heteroaralkyl； In the C 1 -C 28 alkyl, C 1 -C 28 alkoxy, C 2 -C 28 alkenyl, and C 2 -C 28 alkynyl is unsubstituted or substituted by at least one C 1 -C 5 alkyl, C 1 -C 5 alkoxy or hydroxy； R 2 and R 3 are independently of each other hydrogen； C 1 -C 28 alkyl； C 2 -C 28 alkenyl； C 2 -C 22 alkynyl； C 3 -C 12 cycloalkyl； C 3 -C 12 cycloalkenyl； C 7 -C 28 Aralkyl； C 1 -C 20 Heteroalkyl； C 3 -C 12 cyclo-heteroalkyl； C 5 -C 16 heteroaralkyl, and； In the C 1 -C 28 alkyl, C 1 -C 28 alkoxy, C 2 -C 28 alkenyl, and C 2 -C 28 alkynyl is unsubstituted or substituted by at least one C 1 -C 5 alkyl, C 1 -C 5 alkoxy or hydroxy； Or CO-R 5 ； or R 2 and R 3 combine with the bonding nitrogen to form a 5- to 7-membered, monocyclic, carbocyclic or heterocyclic ring； R 5 is C 1 -C 28 alkyl； C 2 -C 28 alkenyl； C 2 -C 28 alkynyl； C 3 -C 12 cycloalkyl； C 3 -C 12 cycloalkenyl； C 7 -C 20 aralkyl； C 1 -C 20 Heteroalkyl； C 3 -C 12 cycloheteroalkyl； C 1 -C 5 alkoxycarbonyl-C 1 -C 5 alkyl； Or C 5 -C 16 heteroaralkyl.ＵＶ 방사선의 유해 효과로부터 인간 및 동물의 모발과 피부를 보호하기 위한 하기 화학식(1)의 2-(2'-히드록시-4'-아미노페닐)벤조트리아졸 유도체가 개시되어 있다: 식 중에서, R1 및 R4는 서로 독립적으로 수소； C1-C28알킬； C1-C28알콕시； C2-C28알케닐； C2-C28알키닐； C3-C12시클로알킬； C3-C12시클로알케닐； C7-C28아르알킬； C1-C20헤테로알킬； C3-C12시클로헤테로알킬； 또는 C5-C16헤테로아르알킬이고； 또 상기 C1-C28알킬, C1-C28알콕시, C2-C28알케닐 및 C2-C28알키닐은 비치환되거나 또는 적어도 1개의 C1-C5알킬, C1-C5알콕시 또는 히드록시에 의해 치환될 수 있으며； R2 및 R3은 서로 독립적으로 수소； C1-C28알킬； C2-C28 알케닐； C2-C22알키닐； C3-C12시클로알킬； C3-C12시클로알케닐； C7-C28아르알킬； C1-C20헤테로알킬； C3-C12시클로-헤테로알킬； C5-C16헤테로아르알킬이고； 또 상기 C1-C28알킬, C1-C28알콕시, C2-C28알케닐 및 C2-C28알
