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Compositions that include 6-aminohexanoic acid derivatives as HDAC inhibitors
专利权人:
BioMarin Pharmaceutical Inc.
发明人:
RUSCHE, James,PEET, Norton,HOPPER, Allen
申请号:
ES09812248
公开号:
ES2620027T3
申请日:
2009.09.03
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof; in which: Y is selected between C (>; = O) and S (>; = O) 2; Ar2 is phenyl; wherein said phenyl is substituted in an ortho position with a group J and with m groups Rz independently selected; L2 is selected from C4 linear chain alkylene, C5 linear chain alkylene and C6 linear chain alkylene, each of which is optionally substituted with 1, 2 or 3 Rx groups; Cy1 is selected from C6-10 aryl; which is substituted with n independently selected Ry groups; L1 is selected from a bond and C1-4 alkylene; R1 is selected from H, C1-4 alkyl and C1-4 haloalkyl; J is amino; each Rx is independently selected from halogen, hydroxyl, C1-4 alkyl and C1-4 alkoxy; each Ry is independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C3-7 cycloalkyl and C2-6 heterocycloalkyl; wherein said C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and C1-6 haloalkoxy are each optionally substituted with 1, 2 or 3 independently selected Ry 'groups; and wherein said C3-7 cycloalkyl and C2-6 heterocycloalkyl are each optionally substituted with 1 or 2 independently selected Ry groups "with the proviso that only one Ry is selected from optionally substituted C3-7 cycloalkyl and C2- heterocycloalkyl. 6; each Rz is independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and C1-6 haloalkoxy; wherein said C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and haloalkoxy C1-6 are each optionally substituted with 1 or 2 independently selected Rz 'groups; each Ry' and Rz 'is independently selected from hydroxyl, C1-4 alkoxy and C1-4 haloalkoxy; each Ry "is independently selected from halogen, hydroxyl , C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy and C1-4 haloalkoxy; n is an integer selected from 0, 1 and 2; and m is an integer selected from 0, 1 and 2.Un compuesto de Fórmula (I):**Fórmula** o una de sus sales farmacéuticamente aceptables; en la que: Y se selecciona entre C(>;=O) y S(
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