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Biomimetic collagen-hydroxyapatite composite material
专利权人:
Geistlich Pharma AG
发明人:
Bufler, Michael
申请号:
AU2014292503
公开号:
AU2014292503B2
申请日:
2014.07.18
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
The invention relates to: - a biomimetic collagen-hydroxyapatite composite material comprising an at least partially fibrous collagen scaffold including mature native collagen fibers possessing triple helicity as shown by Circular Dichroism Spectroscopy, wherein those mature native collagen fibers are at least partially covered with epitactically grown crystals of nanocrystalline hydroxyapatite, whereby the epitactically grown nanocrystals have the same morphology as human bone mineral and the same size as human bone mineral, i.e. a length of 30 to 50 nm and a width of 14 to 25 nm, - a process of preparing the above biomimetic collagen-hydroxyapatite composite material comprising the steps of a) immersing an at least partially fibrous collagen scaffold including the above mature native collagen fibers in a saturated aqueous solution of saturated Ca
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