BCMA嵌合抗原受體及其用途农业专利-农业学术服务平台

发明人:: ABUJOUB, AIDA,艾柏乔　艾达,艾柏喬　艾達,FLEMING, TONY,佛雷明　汤尼,佛雷明　湯尼,HUANG, LU,黄　绿,黃　綠,HONG, CONNIE,洪　康妮,BLANKENSHIP, JOHN,布蓝肯锡　约翰,布藍肯錫　約翰,HOLMBERG, BRIAN,霍姆柏格　布莱恩,霍姆柏格　布萊恩,ZHANG, CHONGHUI,张　重辉,張　重輝,BU, DEXIU

摘要：: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.本發明提供了用於治療與BCMA表現相關的疾病之組成物及方法。本發明還涉及對BCMA具有特異性的嵌合抗原受體(CAR)、編碼其的載體以及包含該BCMA CAR之重組T細胞。本發明還包括施用表現包含BCMA結合結構域的CAR的經遺傳修飾的T細胞之方法。