The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.本發明提供用於治療與CD33表現相關之疾病的組合物及方法。本發明亦關於特異性針對CD33之嵌合抗原受體(CAR),編碼其之載體及包含CD33 CAR之重組T細胞。本發明亦包括投與經遺傳修飾之T細胞的方法,該T細胞表現包含CD33結合結構域之CAR。