TREATMENT OF CANCER USING HUMANIZED ANTI- BCMA CHIMERIC ANTIGEN RECEPTOR农业专利-农业学术服务平台

发明人:: BROGDON, JENNIFER,布拉格登珍妮佛,布拉格登珍妮佛,CHOI, EUGENE,崔优吉妮,崔優吉妮,EBERSBACH, HILMAR,爱伯斯巴赫希尔玛,愛伯斯巴赫希爾瑪,GLASS, DAVID,葛雷斯大卫,葛雷斯大衛,HUET, HEATHER,惠特希儿乐,惠特希兒樂,JUNE, CARL,君卡尔,君卡爾,MANNICK, JOAN,曼尼克琼安,曼尼克

摘要：: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.本發明提供用於治療與BCMA表現相關之疾病的組合物及方法。本發明亦關於特異性針對BCMA之嵌合抗原受體(CAR)、編碼其之載體、及包含BCMA CAR之重組T細胞。本發明亦包括投與經遺傳修飾之T細胞的方法,該T細胞表現包含BCMA結合結構域之CAR。