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New compounds hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
CONTE, AURELIA,HUNZIKER, DANIEL,NEIDHART, WERNER,NETTEKOVEN, MATTHIAS,SCHULZ-GASCH, TANJA
申请号:
ES12721814
公开号:
ES2537591T3
申请日:
2012.05.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compounds of formula (I): ** Formula ** R1 is alkyl, haloalkyl, alkoxyalkyl, haloalkoxyalkyl, hydroxyalkyl, phenyl, substituted phenyl, phenylalkyl, substituted phenylalkyl, phenoxyalkyl, substituted phenoxyalkyl, heteroaryl, substituted heteroarylalkyl or heteroarylalkyl which substituted phenyl, substituted phenylalkyl, substituted phenoxyalkyl, substituted heteroaryl and substituted heteroarylalkyl are substituted with one to three substituents independently selected from alkyl, cycloalkyl, cycloalkylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, haloalkoalkyl, hydroalkyloxy, alkoalkyloxyalkyl, alkyloalkyloxy, , R2 is phenyl, substituted phenyl, heteroaryl or substituted heteroaryl, in which substituted phenyl and substituted heteroaryl are substituted with one to three substituents independently selected from alkyl, cycloalkyl, cycloalkylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, haloalkoxy, hydroxyhaloalkyl and alkoxyhaloalkyl, R3 is hydrogen, hydroxy or alkoxy, in which, in case R3 is hydroxy or alkoxy, E is -C (R5R6) -, R4 is hydrogen, alkyl or cycloalkyl, R5 is hydrogen, alkyl or cycloalkyl, R6 is hydrogen, alkyl or cycloalkyl, n is 1 or 2; A is -N or -CR3; E is a bond or -C (R5R6) -, G is -O-, -NR4-, -CH (OH) -, -C (O) -, -C (O) O-, -C (O) NR4 -, -S (O) 2-, -S (O) 2NR4- or a bond, in which, in the event that E and G are a bond, R1 is directly linked to A, or pharmaceutically acceptable salts of the same, in which: the term "alkyl" refers to a monovalent linear or branched saturated hydrocarbon group with 1 to 7 carbon atoms, the term "cycloalkyl" refers to a monovalent saturated monocyclic or bicyclic hydrocarbon group with 3 to 10 carbon ring atoms, the term "heteroaryl" refers to a monovalent aromatic mono- or bi-cyclic heterocyclic ring system with 5 to 12 ring atoms, comprising 1, 2, 3 or 4 heteroatoms selected from N, O and S, the remaining ring atoms being carbon.Compuestos de fórmula (I):**Fórmula**
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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