BORZA, Istvan,HADADY, Zsuzsa,ELES, Janos,ROMAN, Viktor
申请号：
PE2019001773
公开号：
PE20191646A1
申请日:
2018.03.12
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
It refers to a formula compound I, wherein R1 and R2 are independently selected from h, halogenated, C1-6 tar, etc.； R3 is h, halogenated, C1-6 tar, cyanogen； R4 is C1-6 tar； R5 is C1-6 alternative tar； R6 is h, hydroxy, C1-6 tar, etc.； salt acceptable in medicine, Bioactive new metabolites, prophecy, raccoon, dwarf, troposphere,Their solution and hydrate The preferred compound is acid (3S) - 1 - [5-methyl-6 - (propane-2-il) - 2 - [trans-4 - (trifluoromethyl) cyclohexyl] pirazol [1,5-a] pirimidin-7-il] pirididin-3-carboxilic. These compounds are made of derivatives of pyridylmethane [1,5-a] and replaced by active pharmacological alioligomers. They are the modulators of n-western Sahara of b-bromo receptor. They also refer to the process of producing these compounds, including the pharmacological components of these compounds, which are composed of two or a combination of two compounds. More different therapists, a process to form this component,It can also be used in the treatment or prevention of disorders related to the modulation activity of sugarcane ethanol receptor in Western Sahara, such as anxiety, schizophrenia, epilepsy, etc.Referido a un compuesto de formula I, en donde R1 y R2 se seleccionan independientemente entre H, halogeno, C1-6alquilo, entre otros； R3 es H, halogeno, C1-6alquilo, ciano； R4 es C1-6alquilo； y R5 es C1-6alquilo opcionalmente sustituido； R6 es H, hidroxilo, C1-6alquilo, entre otros； sales farmaceuticamente aceptables, metabolitos biologicamente activos, profarmacos, racematos, enantiomeros, diastereomeros, solvatos e hidratos de los mismos. Un compuesto preferido es acido (3S)-1-[5-metil-6-(propan-2-il)-2-[trans-4-(trifluorometil)ciclohexil]pirazol[1,5-a]pirimidin-7-il]piperidin-3-carboxilico. Estos compuestos son derivados de pirazol[1,5-a]pirimidina sustituidos con aliciclicos farmacologicamente activos y son moduladores alosterico positivo del receptor del GABA B. Tambien se refiere a un proceso para producir dichos compuestos, una
