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Pirimidin-4-ona as a mixed derivative of the target country of angiotensina II receiver and PPAR gamma receiver
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
MAEKAWA, TSUYOSHI,IGAWA, HIDEYUKI
申请号:
PE2011001418
公开号:
PE20120593A1
申请日:
2010.01.29
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
It refers to a non chemical formula compound (I), wherein R1 is h, alternative tar (C1-C6), a group of 3 to 10 members of non aromatic bicycles, and others; R2 is h, tar (C1-C6),Alcoxi(C1-C6),Among others, R3 is h, halogen, oxygen (C1-C6),Y, X and Z are n or Cr4, among which R4 is h, halogen, tar (C1-C6),Bicycle (C3-C6),W is tar (C1-C4), among other things,-O-W...-W'-O--a. W 'is, among other things, a link or tar (C1-C4);A is a different aromatic ring with 5 to 6 members; B is an acid or 3 to 10 member heterosexual. - 2 '-- (5-4-4-4-4-4-4-4-4-4-4-4-4-4-4-4-4-4-4-il) methyl} - 4 - [trans-4 - (2-hydroxi-1, 2-dimethyproposxi) cyclohexal] - 7-prop [1, 2, 4] triazolo [1, 5-A)Pirimidin-5(4H)-Ona;There are others He also mentioned a pharmaceutical composer Are these compounds antagonistic to vascular receptor 2? Initiated by peroxyhormone diffusers in the treatment of hypertension, atherosclerosis, obesitySE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO, UN GRUPO CICLICO NO AROMATICO DE 3 A 10 MIEMBROS, ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS; R3 ES H, HALOGENO, ALCOXI(C1-C6), ENTRE OTROS; Y, X Y Z SON CADA UNO N O CR4, EN DONDE R4 ES H, HALOGENO, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS; W ES ALQUILENO(C1-C4), -O-W'-, -W'-O-, ENTRE OTROS, EN DONDE W' ES UN ENLACE O ALQUILENO(C1-C4); A ES UN ANILLO AROMATICO DIVALENTE DE 5 O 6 MIEMBROS; B ES UN ACILO O UN HETEROCICLICO DE 3 A 10 MIEMBROS. SON COMPUESTOS PREFERIDOS: 4-[TRANS-4-(2-HIDROXI-2-METILPROPOXI)CICLOHEXIL]-6-{[2'-(5-OXO-4,5-DIHIDRO-1,2,4-OXADIAZOL-3-IL)BIFENIL-4-IL]METIL}-7-PROPILPIRAZOLO[1,5-a]PIRIMIDIN-5(4H)-ONA; 6-{[3-FLUORO-2'-(5-OXO-4,5-DIHIDRO-1,2,4-OXADIAZOL-3-IL)BIFENIL-4-IL]METIL}-4-[TRANS-4-(2-HIDROXI-1,2-DIMETILPROPOXI)CICLOHEXIL]-7-PROPIL[1,2,4]TRIAZOLO[1,5-a]PIRIMIDIN-5(4H)-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE ANGIOTENSINA II Y AG
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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