SALES DE DERIVADOS DE 2-AMINO-1-HIDROXIETIL-8-HIDROXIQUINOLIN-2(1H)-ONA QUE TIENEN ACTIVIDAD AGONISTA DEL RECEPTOR B(beta)2 ADRENERGICO ASI COMO ACTIVIDAD ANTAGONISTA DEL RECEPTOR MUSCARINICO M3
JULIA JANE, MONTSERRAT,CARRERA CARRERA, FRANCESC,PRAT QUINONES, MARIA,PUIG DURAN, CARLOS,PAJUELO LORENZO, FRANCESCA,PEREZ ANDRES, JUAN ANTONIO
申请号：
PE0017522015
公开号：
PE16022015A1
申请日:
2014.02.27
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The present Invention relates to pharmaceutically acceptable Addition Salts and Crystal of (i) derived from a sulfonic acid or a derivative or hidroxicarboxilico sulfimida,Or a pharmaceutically acceptable solvate thereof, and (ii) a Derivative of 2 - amino - 2 - hydroxyethyl hidroxiquinolin - 8 - 2 (1H) - one of formula (i) wherein: R1 represents a hydrogen Atom or a Group c1-c4 alkyl R2 and R3 independently represent a hydrogen Atom, a Halogen Atom,Etc a represents a group alquileno c1-c4 optionally substituted with one or more alkyl groups C1 - C2 l represents a direct link, a - NH - Group (CO), etc.The salts are preferred: etanodisulfonato of Hydroxy (di - (2-thienyl) Trans - 4 - ((3 - (2 - Chloro - (4 - ((2R) - 2 - hydroxy - 2 - 8 - hydroxy - 2 - oxo - 1.2 - dihidroquinolin IL - 5 - methyl) ethylamino)) - 5 - metoxifenilamino) - 3-oxopropyl) cyclohexyl (methyl) amino) - disacarinato 2 - hydroxy - 2 - di (thiophen-2-yl) acetate trans 4 - ((2 - (2 - Chloro - (4 - ((R) - 2-hydroxy-2 - (8 - hydroxy - 2 - oxo - 1Dihidroquinolin - 2 - 5 - il) ethylamino) - methyl) - 5 - metoxifenilcarbamoiloxi) ethyl) - cyclohexyl (methyl) amino) - and L - Tartrate salt 2 - hydroxy - 2 - di (thiophen-2-yl) acetate trans-4 - ((2 - (2 - chlorine - (4 - ((R) - 2-hydroxy-2 - (8 - hydroxy - 2 - oxo - 1.2 - dihidroquinolin - 5 - il) ethylamino) - methyl) - 5 - (meth) ethyl) - metoxifenilcarbamoiloxi IL) amino) cyclohexylLa presente invencion se refiere a sales de adicion cristalinas y farmaceuticamente aceptables de (i) derivados de un acido sulfonico o hidroxicarboxilico o un derivado sulfimida, o un solvato farmaceuticamente aceptable del mismo y (ii) un derivado de 2-amino-1-hidroxietil-8-hidroxiquinolin-2(1H)-ona de formula (I) donde: R1 representa un atomo de hidrogeno o un grupo alquilo C1-C4 R2 y R3 independientemente representan un atomo de hidrogeno, un atomo de halogeno, etc A representa un grupo alquileno C1-C4 opcionalmente sustituido con uno o mas grupos alquilo C1-C2 L represe
