Salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2 (1H) -one derivatives that have both agonist activity towards adrenergic receptor 2 and antagonistic activity towards muscarinic receptor M3
CARRERA CARRERA, Francesc,PAJUELO LORENZO, Francesca,PEREZ ANDRES, Juan Antonio,PRAT QUINONES, Maria,PUIG DURAN, Carlos,JULIA JANE, Montserrat
申请号：
ES14706652
公开号：
ES2674085T3
申请日:
2014.02.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A pharmaceutically acceptable crystalline addition salt which is one of trans-4 - ((3- (2-chloro-4 - (((2R) -2-hydroxy-2-) hydroxy (di-2-thienyl) ethanedisulfonate) (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethylamino) methyl) -5-methoxyphenylamino) -3-oxopropyl) methyl) amino) -cyclohexyl, 2-hydroxy-2,2- discarinate di (thiophen-2-yl) trans-4 acetate - ((2- (2-chloro-4 - (((R) -2-hydroxy-2- (8-hydroxy-2-oxo-1,2- dihydroquinolin-5-yl) ethylamino) -methyl) -5-methoxyphenyl-carbamoyloxy) ethyl) - (methyl) amino) -cyclohexyl and 2-hydroxy-2,2-di (thiophene-2-yl) acetate L-tartrate of trans-4 - ((2- (2-chloro-4 - (((R) -2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethylamino) - methyl) -5-methoxyphenylcarbamoyloxy) ethyl) - (methyl) amino) cyclohexyl, or a pharmaceutically acceptable solvate thereof.Una sal de adición cristalina farmacéuticamente aceptable que es una de etanodisulfonato de hidroxi(di-2-tienil)acetato de trans-4-((3-(2-cloro-4-(((2R)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2- dihidroquinolin-5-il)etilamino)metil)-5-metoxifenilamino)-3-oxopropil)metil)amino)-ciclohexilo, disacarinato de 2-hidroxi-2,2-di(tiofen-2-il)acetato de trans-4-((2-(2-cloro-4-(((R)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2- dihidroquinolin-5-il)etilamino)-metil)-5-metoxifenil-carbamoiloxi)etil)-(metil)amino)-ciclohexilo y L-tartrato de 2-hidroxi-2,2-di(tiofen-2-il)acetato de trans-4-((2-(2-cloro-4-(((R)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2- dihidroquinolin-5-il)etilamino)-metil)-5-metoxifenilcarbamoiloxi)etil)-(metil)amino)ciclohexilo, o un solvato farmacéuticamente aceptable de las mismas.
