JOSEPH BUTLER,CHRISTOPHER JOHN JONES,AMIT ARORA,KASSIE TERRA-LYNN BETTS,SIMON LEWIS BILTON,GAREN KOUYOUMJIAN
申请号:
ARP120104901
公开号:
AR089397A1
申请日:
2012.12.21
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
This table lists the sulfamidopyridine compounds with antithrombotic activity, especially inhibiting IXA and / or XA coagulation factors, as well as their preparation and use as drugs. Claim 1: an equation compound (1), wherein: R1 represents hydrogen atom, a Coking Group c832131;a C₃₋₇ cycloalkyl group,a C₃₋₇-C₁₋₆ alkyl cycloalkyl group,a Rᵇ-O-Rᵃ- group where Rᵇ represents a C₁₋₆ alkyl group or a C₃₋₇ cycloalkyl group and Rᵃ represents a C₁₋₆ alkyl group,or an Rᵈ-O-C (O) -O-Rᶜ- group where Rᵈ represents a C₁₋₆ alkyl group or a C₃₋₇ cycloalkyl group and Rᶜ represents a C₁₋₆ alkyl group,or a group Rᶠ-C (O) -O-Rᵉ- where Rᵉ represents a C₁₋₆ alkyl group and Rᶠ represents a C₁₋₆ alkyl group;R² represents a halogen atom, -OH, -CN or a C₁₋₆ alkyl group or a -O-C₁₋₆ alkyl group,In these groups, one or more of the same or different halogen atoms are not substituted or substituted,or an Rᵍ-O-Rʰ-O group where Rᵍ represents a C₁₋₆ alkyl group and Rʰ represents a C₁₋₆ alkyl group;RZ represents hydrogen atom or c8332121 tar group;R 3 is a group of formulas (2) or (3);R⁴ and R⁵ represent, independently of one another, a C₁₋₆ alkyl group or a C₃₋₇ cycloalkyl group,O r83088 and r83099 together form an abiotic group of 3 to 7 members, consisting of 1 to 2 abiotic atoms selected from nitrogen, oxygen and sulfur, in which none or more of the same or different groups replace or replace.a. Selected from halogen atom and tar group;C₁₋₆ alkoxy groups,-CF8323,-OCF8323;R⁶ represents a halogen atom, a hydrogen atom, a C₁₋₆ alkyl group,a C₁₋₆ or -CN alkoxy group; as well as its enantiomers, diastereoisomers and mixtures thereof, and their pharmaceutically acceptable salts.La presente se refiere a compuestos de sulfonilaminopirrolidinona que presentan una actividad antitrombótica que, en particular, inhibe el factor de coagulación IXa y/o el factor Xa, a procesos para su preparación y a su uso como fármacos. Reivindicación 1: Un compuesto de fórmula (1) donde: R¹ representa un átomo de hidróge