FREYNE, EDDY JEAN EDGARD,费艾迪,費艾迪,VAN EMELEN, KRISTOF,范继道,范繼道,BUIJNSTERS, PETER JACOBUS JOHANNES ANTONIUS,布彼得,布彼得,EMBRECHTS, WERNER CONSTANT JOHAN,艾维纳,艾維納,PERERA, TIMOTHY PIETRO SUREN,贝提姆,貝提姆
申请号：
TW093139380
公开号：
TWI374879B
申请日:
2004.12.17
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The compound of this Hair Ming You Off following formulas(I)The Jia Cheng Which being subjected on its N- oxide form, Medical Drug are Ji Li Bodyization Learn Iso Agencies forms, wherein Z Department indicate NHY Department expression-C3-9 alkyl-,-C1-5 alkyl-NR12-C1-5 alkyl-,-C1-6 alkyl-NH-CO- or-CO-NH-C1-6 alkyl-X1 Department expressions-O-X2 Department indicate Zhi Jie Key Knot ,-NR11-C1-2 alkyl-,-NR11-CH2- ,-C1-2 alkyl-,-O-C1-2 alkyl-,-O- or-O-CH2-R1 Department indicate Hydrogen Huo Halogen basesR2 Department indicate Hydrogen, cyano, Halogen Ji, Hydroxyalkyl bases carbonyl-, C1-4 alkyloxycarbonyls-, Het16- carbonyls or Ar5R3 Department indicate that Hydrogen, Hydroxyalkyl base, C1-4 alkyl oxies-, Ar4-C1-4 alkyl oxies or R3 Department indicate The mono- or may two or Duo Ge Election C1-4 alkyl oxies replaced the substituent group of C1-4 alkyl oxies-or Het2-R10 Department indicate HydrogenR11 Department indicate Hydrogen, C1-4 alkyl-or C1-4 alkyl-oxygroup-carbonyl-R12 Department indicate Het14-C1-4 alkyl, especially Do quinolines base-C1-4 alkylDo quinolines base or piperidyl Miscellaneous Ring Het2 Department Biao Shi Election replaced from Visual Qing Condition The C1-4 alkyl-(good with methyl As)Het14 Department indicate Do quinolines baseHet16 Department Biao Shi Election are from Do quinolines base or pyrrolidinyl Miscellaneous RingAr4 Department indicate phenylAr5 Department indicate the replaced phenyl of Visual Qing Condition The cyano.本發明有關下式之化合物(I)其N-氧化物形式、醫藥上可接受之加成鹽及立體化學異構形式,其中Z係表示NH;Y係表示-C3-9烷基-、-C1-5烷基-NR12-C1-5烷基-、-C1-6烷基-NH-CO-或-CO-NH-C1-6烷基-;X1係表示-O-;X2係表示直接鍵結、-NR11-C1-2烷基-、-NR11-CH2-、-C1-2烷基-、-O-C1-2烷基-、-O-或-O-CH2-;R1係表示氫或鹵基;R2係表示氫、氰基、鹵基、羥基羰基-、C1-4烷基氧基羰基-、Het16-羰基或Ar5;R3係表示氫、羥基、C1-4烷基氧基-、Ar4-C1-4烷基氧基或R3係表示經一或可能二或多個選自C1-4烷基氧基-或Het2-之取代基所取代的C1-4烷基氧基;R10係表示氫;R11係表示氫、C1-4烷基-或C1-4烷基-氧基-羰基-;R12係表示Het14-C1-4烷基,尤其是嗎啉基-C1-4烷基;Het2係表示選自視情況經C1-4烷基-(以甲基為佳)所取代之嗎啉基或哌啶基的雜環;Het14係表示嗎啉基;Het16係表示選自嗎啉基或吡咯烷基之雜環;Ar4係表示苯基;Ar5係表示視情況經氰基所取代之苯基。
