AHN, YOUNG GIL,SONG, JI YOUNG,PARK, CHANG HEE,KIM, WON JEOUNG,KIM, JI SOOK,BAE, IN HWAN
申请号：
ARP180102593
公开号：
AR112900A1
申请日:
2018.09.12
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
The compounds provided have a specific lysine-1 inhibitory activity of lysine (LSD1),1. Optical isomer, solution, Tao Qiang meter or acceptable salt in these substances can effectively prevent or treat diseases caused by abnormal activation of LSD1. Claim 1: compound (1) represented by formula,An optical isomer, a solution, or a tautometer, or a salt acceptable from it, characterized in formula (1),(b) Ring B is a carbon thyroid group c833231 and 83238320j8320jo, or a different cycle group c833318323238320jb；X is C (r83099a) or N； each R1 to r83099 is a radical unit price selected independently from hydrogen, halogen, cyanogen compound, hydrogen based compound, sulfur compound, nitrogen group, c8332183318322 asphalt or unreplaced asphalt group, alquenilo c832283331； (c8320 replaced or unreplaced asphalt group)； a. Replacing or not replacing a c833231838322 carbon thyroid group； replacing or not replacing a c8332183318322； replacing or not replacing an alcoxic c83321833183222； replacing or not replacing a c833183228331； replacing or not replacing a c833228321； replacing or not replacing a c83322832838 and c2183283183208383 replaced by c833220；a. Ariloxi c83326318322；； 8320 ariltio c8332626 replaced or not replaced； ariltio c833318322 replaced or not replaced； c831218c83221 replaced or not replaced； c83321833183222 replaced or not replaced； c8332183228320 replaced or not replaced； c833183318320 replaced or not replaced； a. One arilo c83268331-83222； one c832188322 with or without replacement； - n (Q1) (Q2) with or without replacement；-C（=O）（Q1），-N-C（=O）（Q1），-N-C（=O）-N（Q1）（Q2），-O-C（=O）（Q1），-S（=O）（Q1），-S（=O）832222（Q1），-P (= O) (Q1) (Q2) and - N-C (= NH) - n (Q1) (Q2),When R1 (s) or R2 (s) are two or more optional ones, two R1 (s) or R2 (s) should be used as substitutes for the two atoms surrounding the ring and connected with the corresponding ring, Two adjacent substitutes R1 (s) or R ř (s) are connected with each other to form a c8332331832383238320 replaced or not re
