Production of a polyphenol-based cocoa bean extract (I) comprises (a) obtaining clean, pulp- and shell-free kernels from fresh (i.e. non-pretreated and non-defatted) beans, (b) grinding the kernels in presence of solvent(s), (c) macerating to extract the desired components, (d) filtering and (e) recovering (I) (see figure). An independent claim is included for polyphenol-based extracts (I'), containing (by weight) 15-65% polyphenols, 0-11% lipids and 5-20% xanthines. ACTIVITY : Cardiant； anticoagulant； antiarteriosclerotic； vasotropic； ophthalmological； hypotensive； antilipemic； antiinflammatory； vulnerary； virucide； antibacterial； neuroprotective； nootropic； cytostatic； immunostimulant； antidiabetic； antiulcer； antipyretic； tranquilizer； analgesic； antipsoriatic； antirheumatic； antiarthritic； anti-HIV. MECHANISM OF ACTION : Antioxidant； radical scavenger. An extract (Ia) obtained from ground, fresh cocoa beans by maceration with water at 60[deg]C for 24 hours had a DPPH value (a measure of antiradical activity) of 147.6.
