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RETINOID-CONTAINING COMPOSITIONS FOR LOCAL USE OF "OIL IN WATER" EMULSION TYPE
专利权人:
ГАЛДЕРМА РЕСЕРЧ ЭНД ДЕВЕЛОПМЕНТ (FR)
发明人:
ДЮПРА Аньес (FR),МАЛЛАР Клер (FR)
申请号:
RU2014152998
公开号:
RU2014152998A
申请日:
2013.05.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A composition of the type of an oil-in-water emulsion, comprising: an oil phase comprising: a compound of general formula (I): wherein: R represents a hydrogen atom, alkyl containing from 1 to 4 carbon atoms, or —CF; R represents an atom hydrogen, an alkyl or alkoxy group containing from 1 to 4 carbon atoms, or a chlorine atom; R represents a hydrogen atom, an alkyl or alkoxy group containing from 1 to 10 carbon atoms, which is linear or branched and optionally having a methoxy group as a substituent; R represents hydrogen atom alkyl containing from 1 to 3 carbon atoms; R represents a hydrogen atom or alkyl containing from 1 to 3 carbon atoms; or R and R together with the —NC (= Y) fragment form a cycle such as pyrrolidine, pyrrolidinone, piperidine or piperidinone; Y represents are two hydrogen atoms or a heteroatom such as an oxygen atom, sulfur; Ar is a cycle of 1,4-phenyl, 2,5-pyridyl, 5,2-pyridyl or 2,5-thiophenyl; X is an oxygen atom having alkyl or alkylamine or a single C — C bond as a substituent; A is th hydrogen atom or a group of the following formula: where: Q represents an oxygen atom or a linker - NH-; R represents a hydrogen atom, alkyl containing from 1 to 6 carbon atoms, cycloalkyl containing from 3 to 6 carbon atoms, -C ( O) CH or —C (O) CHCH; R and R ′ independently represent hydrogen atoms or hydroxy groups, provided that R and R ′ do not simultaneously represent a hydroxy group; n is 0, 1, 2, 3, 4 or 5 at least one basic solvent of compound (I) and at least one oily auxiliary solvent l compounds (I), and the aqueous phase containing at least one gel1. Композиция типа эмульсии "масло в воде", содержащая:- масляную фазу, содержащую:соединение общей формулы (I):где:Rпредставляет собой атом водорода, алкил, содержащий от 1 до 4 атомов углерода, или -CF;Rпредставляет собой атом водорода, алкил или алкоксигруппу, содержащую от 1 до 4 атомов углерода, или атом хлора;Rпредставляет собой атом водорода, алкил или алкоксигруппу, содержащую от 1 до 10 а
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