SHANGHAI INSTITUTE OF MATERIA MEDICA; CHINESE ACADEMY OF SCIENCES
发明人:
Kan DING,Yanling LI
申请号：
US16327270
公开号：
US20190218540A1
申请日:
2017.08.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A method for preparing a model of an animal suffering from non-human mammal obesity or a related disease, comprising the following steps: (a) providing a cell of a non-human mammal, and inactivating Glce gene in the cell, thereby obtaining a non-human mammal cell with an inactivated Glce gene； and (b) using the cell having an inactivated Glce gene obtained in step (a) to prepare and obtain a model of an animal suffering from Glce gene-inactivated obesity or a related disease. The animal model is an effective model for an animal suffering from obesity or a related disease, which may be used for researching diseases such as obesity, hyperlipidemia, hypertension, and diabetes, and may also be used for screening and testing experiments of specific drugs.
