Chinese Academy of Sciences;Shanghai Institute of Materia Medica
发明人:
DING, Kan,LI, Yanling
申请号：
EP17842913
公开号：
EP3505190A4
申请日:
2017.08.22
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
A method for preparing a non-human mammalian animal model suffering from obesity or a related disease, comprising the following steps: (a) providing a non-human mammalian cell, and inactivating Glce gene in the cell, thereby obtaining a non-human mammalian cell with an inactivated Glce gene； and (b) using the cell with the inactivated Glce gene obtained in step (a) to prepare and obtain an animal model suffering from Glce gene-inactivated obesity or related diseases. The animal model is an effective animal model suffering from obesity or a related disease, and is useful for researching diseases such as obesity, hyperlipidemia, hypertension, and diabetes, and is useful for in experiments for screening and testing specific medicines.
