The invention relates to a machine for the treatment of infectious waste in order to obtain its sterilization and more specifically to an autoclave to be inserted in the processing cycle of medical waste in order to disinfect and neutralize the biological agents by means of the inactivation of the pathogenic microorganisms virus and sporogenic bacteria contained therein. The autoclave is provided with two chambers: an internal and an external one where high pressure saturated steam is injected the external chamber keeps warm the walls avoiding steam condensation and resulting leachate.