Embodiments relate generally to systems and methods for sterilizing a container comprising a liquid, where a method may comprise placing the container within an autoclave vessel； pressurizing the autoclave vessel to an initial pressure, by pressurizing the autoclave vessel with a clean gas via a first valve； after pressurizing the autoclave vessel to the initial pressure, heating the autoclave vessel to sterilize the liquid within the container within the autoclave vessel； controlling the pressure within the autoclave vessel while heating the autoclave vessel to maintain a pressure within ±10% of the initial pressure via a second valve； and cooling the autoclave vessel after sterilization.
