Colussi, Paul,Bednenko, Janna,Bisharyan, Yelena,Papoyan, Ashot,Cardarelli, Joanna,Clark, Theodore G.,Kahn, R. Douglas,Marien, Lore,Van Der Woning, Bas,De Haard, Hans,Harriman, William D.,Collarini, El
申请号：
AU2017260232
公开号：
AU2017260232A1
申请日:
2017.05.02
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Anti-Kv1.3 antibodies (mAbs), particularly mAbs that specifically bind to Kv1.3 with high affinity and/or inhibit Kv1.3 function, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-Kv1.3 mAbs are provided. Additionally, canonical structures for CDRs in the VH and VL regions of anti-Kv1.3 antibodies are provided. The disclosure also provides nucleic acid molecules encoding the anti-Kv1.3 mAbs, expression vectors, host cells, methods for making the anti-Kv1.3 mAbs, and methods for expressing the anti-Kv1.3 mAbs. Finally, methods of using the anti-Kv1.3 mAbs as therapeutics, such as for preventing or treating an autoimmune disorder, are disclosed.
