PROTEIN A BINDING POLYPEPTIDES, ANTI-EPHA2 ANTIBODIES AND METHODS OF USE THEREOF

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专利权人:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:

MARKS, JAMES D.,DRUMMOND, DARYL,GEDDIE, MELISSA,KIRPOTIN, DMITRI,KOHLI, NEERAJ,LUGOVSKY, ALEXEY

申请号：

CA3016676

公开号：

CA3016676A1

申请日:

2017.03.13

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Provided by the present disclosure are antibodies (e.g., scFvs) that include CDRs and human framework regions that confer useful properties upon the antibodies. In certain embodiments, such properties include thermostability (e.g., increased melting temperature), efficient binding to Staphylococcus aureus Protein A, or both. In certain aspects, the antibodies are internalizing antibodies that specifically bind to the tumor associated antigen EphA2.

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