#$%^&*AU2020101589A420201015.pdf#####ABSTRACT The invention provides a Lactobacillus Brevis ZJ401 with antioxidant activity and its application. The strain is preserved in China Center for Type Culture Collection with address Wuhan University, Wuhan, China, zip code 430072, preservation number CCTCC M 2017666, and preservation date: November 7, 2017. It can significantly increase the activities of SOD and CAT in A549 cells, significantly reduce the content of LDH and ROS in cell supernatant, and significantly increase the expression of Nrf2 and y - GCS genes in Caco-2 cells. The Lactobacillus brevis ZJ401 was prepared into powder and then made into antioxidant food or health products, which can be eaten or drunk directly. It is easy to use and can enhance the immunity of the body. The Lactobacillus brevis ZJ401 has important research significance and application prospects for the development of live microorganismal agent and functional fermented dairy products.-1/6e aFigure1