To provide a method for producing lactic acid bacteria in which the activity of inducing the production of IL-10 having a function of suppressing an excessive immune response remains and the production inducing activity of IL-12 having a function of causing an excessive immune response has almost disappeared, And an immunomodulatory composition comprising the same as an active ingredient.SOLUTION: Lactic acid bacteria belonging to Lactobacillus pentosus and having IL-10 production inducing activity and IL-12 production inducing activity are cultured while adding an alkaline agent so as to suppress a decrease in pH associated with the culture, IL-10 production-inducing activity remains, and IL-12 production-inducing activity is almost eliminated to produce lactic acid bacteria.BACKGROUND OF THE INVENTION【課題】過剰な免疫応答を抑える働きをもつIL-10の産生誘導活性が残存し、且つ、過剰な免疫応答を引き起こす働きをもつIL-12の産生誘導活性がほとんど消失した乳酸菌の製造方法、及びそれを有効成分とする免疫調節用組成物を提供する。【解決手段】ラクトバシルス・ペントーサスに属し、IL-10産生誘導活性及びIL-12産生誘導活性を有する乳酸菌を、培養に伴うpHの低下を抑制するようにアルカリ剤を添加しつつ培養することにより、IL-10産生誘導活性が残存し、IL-12産生誘導活性がほとんど消失した乳酸菌を生産する。【選択図】 図1
