The present invention discloses a method for manufacturing red mold dioscorea, and the method comprises the following steps: adding some water with an appropriate ratio to fresh dioscorea or dried dioscorea sterilizing the dioscorea after the dioscorea being cooled down, inoculating the dioscorea with Monascus species cultivating the dioscorea with an appropriate temperature, an appropriate humidity and an appropriate shacking frequency for an appropriate time period and drying the cultivated red mold dioscorea with an appropriate water content.