This invention wounding which is obtained from the bromelain clearly regards the composition and its production method. Especially, this invention includes the proteolytic enzyme which possesses the molecular weight of approximately 23kDa, the bromelain inhibiter wounding which is obtained from the bromelain which is not included essentially clearly regards the composition, and the medicine composition which includes that. Wounding clearly the composition and the medicine composition which includes that wounding the especially skin organization clearly and are useful in healing of wound.本発明は、ブロメラインから得た創傷清拭組成物及びその製造方法に関する。特に、本発明は、約23kDaの分子量を有する蛋白質分解酵素を含み、ブロメライン阻害剤を本質的に含まないブロメラインから得た創傷清拭組成物、及びそれを含む医薬組成物に関する。創傷清拭組成物及びそれを含む医薬組成物は、特に痂皮組織の創傷清拭及び創傷治癒に有用である。
